To treat mild bugs avoiding antibiotics may help preserve drug effectiveness for severe infections. Development of alternative treatments for mild infections could help to slow the advancement and spread of antibiotic resistance.
Alternative treatments for certain mild infections could cause keep up the ability to utilize antibiotics against the severe infections for which new medications have been hard to develop.
Most research to identify alternatives to antibiotics, for example, bacteria-killing viruses, has focused on targeting on bugs responsible of severe infections utilizing alternative treatments. However, such efforts have met with limited success.
To identify approaches that may be more successful, Waldetoft and Brown reviewed previous studies of antibiotics utilize.
They utilized an evolutionary framework to analyze information from these examinations and determined that widespread use of antibiotics against certain mild infections may contribute essentially to the advancement of antibiotic resistance.
This is, to some extent, because antibiotics can select for resistance in any bacteria present in a patient, not simply in the target bug. And since many antibiotics operate in comparable ways, a single antibiotic can promote resistance to many medications.
Thus, they concluded that research efforts to develop alternative treatments should shift focus from the severe infections to milder ones.
For certain mild infections, the analysis suggests that alternative treatments, which might be simpler to develop in more dangerous bug and could indirectly slow development of antibiotic resistance.
This could help to keep up the capacity to utilize antibiotics against severe infections for which new medications have been hard to develop.
The authors take note of that improvement of non- antibiotic alternatives for mild infections is only one technique to combat antibiotic resistance.
Different techniques include shorter courses of antibiotic treatment and utilization of antibiotics that act against a narrower range of species.