ICMR-Tests Efficacy of Two drugs for Handling TB

With India set to witness a steep rise in the number of drug-resistant tuberculosis cases, the Indian Council of Medical Research (ICMR) will test the safety and efficacy of two new medicines for handling the dreaded bug that causes TB.

The ICMR is intending to test the efficacy of two medicines Metformin and Bedaquiline Delaminate for handling drug-resistant tuberculosis. One of the medicines, Metformin, is broadly used to treat type 2 diabetes. In any case, ICMR plans a clinical trial to examine its effectiveness in fighting the TB organism following encouraging scientific outcomes from Indian biologists, reports Deccan Herald.

Research recommends that metformin, which controls glucose levels, acts as a defensive agent against TB regardless of whether somebody has diabetes or not.

“The drug decreases inflammation, improves immune response and the efficacy of conventional TB drugs. Some research has even demonstrated that it enhances control of TB contamination and reduces infection severity. We need to see whether this will work in as adjunctive treatment for improving the effective treatment of TB in our populace.

The second medication is Bedaquiline that received the US Food and Drug Administration’s approval in 2012 for the treatment of drug-resistant tuberculosis cases. It is yet to be utilized as a part of India’s public funded national TB control program.

“The protocol for the Metformin trial is prepared and we would like to begin the trial within two or three months. The Bedaquiline Delaminate (another new medication) trial for drug-resistant cases may take around a half year to commence,” ICMR chief general Soumya Swaminathan told DH.

The Metformin trial would be held in two steps. To begin with, there would be a phase-II proof-of-concept trial on a limited number of patients to examine the safety of the drug in TB treatment. It would be followed by a larger trial on the drug’s efficacy and for dosage determination.

Physicians say the relationship amongst TB and diabetes isn’t new. Currently, patients testing positive for diabetes at government facilities are referred to undergo examination for TB. TB patients are additionally made a request to check their blood glucose levels.

In 2016, a guideline was framed by the focal TB division after examinations indicated individuals with diabetes had 2-3 times higher risk of contracting TB. TB patients are also made a request to check their blood glucose levels.

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