Obesity May Be Caused By High Insulin

A new genetic study gives evidence that a higher insulin level is a key causal factor in weight gain. The way the study is run provides useful food for thought about why a few people develop obesity while others don’t.

It additionally adds to the discussion about what should be possible to limit the weight gain that is occurring in almost every country. There are two theories with reference to why individuals grow obese.

One is that high-calorie intake and too few calories being burned off leads to weight gain. Alternate proposes too much carbohydrate which advances high levels of insulin, the fat storage hormone, causes weight gain.

The calories in, calories out theory is the theory most discussed by medical experts, charities, and the media. In any case, the theory has its critics as it doesn’t explain why a few people have a high-calorie intake yet stay slim while someone else may have a lower calorie intake and put on weight notwithstanding being just as active.

The carbohydrate-insulin model is less discussed in the media but has been gaining traction in research circles. In the genetic study, the scientists from Boston Children’s Hospital utilized a technique to research how different genetic traits influenced obesity called Mendelian randomisation.

Mendelian randomisation is an effective research method for exploring causation as it is more stronger at controlling against reverse around causation and confounding factors. Reverse causation and confounding factors are two main reasons why many studies into possible causal impacts can just give associations as opposed to strong causal evidence.

The scientists evaluated genetically determined higher insulin secretion on BMI and genetically determined higher BMI on greater insulin secretion. The outcomes demonstrated that being genetically predisposed to have higher insulin secretion led to a greater a BMI. Notwithstanding, being genetically predisposed to have a greater BMI did not lead to greater insulin secretion.

Specialist Dr. David Ludwig commented on their discoveries: “We found that genetically-determined insulin secretion predicted body mass index with extremely high confidence and potentially large impact on the populace.”

By running the study from two directions, the scientists could demonstrate that higher insulin leads to high BMI while reverse causality was indicated not to apply.

This gives stronger confirmation that a high insulin leads to obesity that would be possible with regular epidemiological examinations. Dr. Ludwig included: “Of specific significance, the ‘reverse’ relationship was null.

That is, genetically determined body mass index did not predict insulin secretion to any degree.”

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