Vitamin D Rapidly Reduce Arterial Stiffness in overweight vitamin-deficient African-Americans

In only four months, high doses of vitamin D reduced arterial stiffness in young, overweight/ obese, vitamin- deficient, but generally still healthy African-Americans, scientists say.

Yanbin Dong, MD, Ph.D., geneticist and cardiologist at the Georgia Prevention Institute (GPI) at the Medical College of Georgia (MCG) at Augusta University says, rigid artery walls are an independent predictor of cardiovascular-related disease and death, and vitamin D deficiency seems, to be a contributor.

So scientists looked at baseline and again four months after the fact in 70 African-Americans 13 to 45 years old every one of whom had some degree of arterial stiffness taking varying doses of the vitamin best known for its role in bone health.

In the journal  PLoS ONE they wrote, in what has seemed to be the first randomized trial of its kind, they found that arterial stiffness was improved by vitamin D supplementation in a dose-response manner in this populace.

The study’s corresponding author Dong says overweight/ obese blacks are at increased risk for vitamin D lack because darker skin absorbs less sunlight the skin makes vitamin D in response to sun exposure and fat has a tendency to sequester vitamin D for no apparent reason.

Dr. Anas Raed, MD, research resident in the MCG Department of Medicine and the study’s first author says, members, taking 4,000 international units (IU) more than six times the daily 600 IU the Institute of Medicine currently suggests for most adults and children received the most benefit.

Raed says, the dose now considered the highest safe upper dosage of the vitamin by the Institute of Medicine, reduced arterial stiffness the most and the fastest: 10.4% of every four months. Stiffness was essentially and quickly reduced.

Two thousand IU decreased stiffness by 2% in that time period. At 600 IU, over the time period arterial stiffness actually increased slightly (0.1%), and the placebo group experienced a 2.3% increase in arterial stiffness.

The scientists utilized noninvasive, gold-standard pulse wave velocity to assess arterial stiffness. Reported measures were from the carotid artery in the neck to the femoral artery, a major blood vessel, which supplies the lower body with blood.

The American Heart Association considers this the primary result measurement of arterial stiffness. The varying doses, and also the placebo members took, were altogether packaged the same, so neither they nor the investigators knew which dosage if any, individuals were getting until the point when the study was finished.

Both placebo and supplements were given once monthly rather than daily at home at the GPI to ensure consistent compliance.

While heart disease is the main cause of death in the United States, as per the Centers for Disease Control and Prevention, African-Americans have higher rates of cardiovascular disease and death than whites and the disease has a tendency to happen prior throughout in life.

The authors write that arterial stiffness and vitamin D lack may be potential contributors. Exactly how vitamin D is useful for our arteries isn’t totally understood, however, it seems to impact vein blood vessel health in many ways.

Raed says laboratory studies have demonstrated that mice missing a vitamin D receptor have higher activation of the renin-angiotensin-aldosterone system.

To arterial stiffness activation of this system contributes increases blood vessel constriction. Vitamin D can also suppress vascular smooth muscle cell proliferation, activation of garbage-eating macrophages, and calcification formation, all of which can thicken blood vessel and hinder flexibility. Vitamin D decreases inflammation, an underlying mechanism for the obesity-related development of coronary artery disease.

Presently time to complete a larger-scale study, especially in high- risk populaces, and follow participants’ progress for longer periods, Dong and Raed say. “A year would give us considerably more information and ideas,” Raed includes.


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